Modulators of HIF1a and NFkB in Cancer treatment: Is it a rational approach for controlling malignant progression?

Modulators of HIF1a and NFkB in Cancer treatment: Is it a rational approach for controlling malignant progression?

HIF1 and NFkB are two transcription factors very frequently activated in tumors and involved in tumor growth, progression and resistance to chemotherapy. In fact, HIF1 and NFkB together regulate transcription of over a thousand genes that, in turn, control vital cellular processes such as adaptat...

Full description

Bibliographic Details
Main Authors: Marco eTafani, Bruna ePucci, Andrea eRusso, Luana eSchito, Laura ePellegrini, Giulietta A Perrone, Lidia eVillanova, Luisa eSalvatori, Linda eRavenna, Elisa ePetrangeli, Matteo A Russo
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Pharmacology
Subjects:
Inflammation
Cancer
hypoxia
HIF1 inhibitors
NFkB inhibitors
Sirtuin activators
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00013/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00013/full

Similar Items