miR-7 and miR-153 protect neurons against MPP+- induced cell death via upregulation of mTOR pathway

miR-7 and miR-153 protect neurons against MPP+- induced cell death via upregulation of mTOR pathway

Differential expression of microRNAs (miRs) in the brain of patients with neurodegenerative diseases suggests that they may have key regulatory roles in the development of these disorders. Two such miRs, miR-7 and miR-153 have recently been shown to target α-synuclein, a protein critically involved...

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Bibliographic Details
Main Authors: Apostolia eFragkouli, Epaminondas eDoxakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neurons
Parkinson Disease
Neuroprotection
Bcl-2
rapamycin
caspase-3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00182/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00182/full

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