Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects

Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects

Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction...

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Bibliographic Details
Main Authors: Eleonora Gallerani, Davide Proietto, Beatrice Dallan, Marco Campagnaro, Salvatore Pacifico, Valentina Albanese, Erika Marzola, Peggy Marconi, Antonella Caputo, Victor Appay, Riccardo Gavioli, Francesco Nicoli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
immune aging
naive T cells
cellular immunity
epitopes
primary responses
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.693054/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.693054/full

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