TREM2-Dependent Effects on Microglia in Alzheimer’s Disease

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease

Alzheimer’s disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits. Abnormal protein aggregates in the AD brain are also associated with reactive microglia and astrocy...

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Bibliographic Details
Main Authors: Yingyue Zhou, Tyler K. Ulland, Marco Colonna
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
microglia
TREM2
metabolism
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00202/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00202/full

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