The Reality of Randomized Controlled Trials for Assessing the Benefit of Proton Therapy: Critically Examining the Intent-to-Treat Principle in the Presence of Insurance Denial

The Reality of Randomized Controlled Trials for Assessing the Benefit of Proton Therapy: Critically Examining the Intent-to-Treat Principle in the Presence of Insurance Denial

Purpose: This study hypothesized that insurance denial would lead to bias and loss of statistical power when evaluating the results from an intent-to-treat (ITT), per-protocol, and as-treated analyses using a simulated randomized clinical trial comparing proton therapy to intensity modulated radiati...

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Bibliographic Details
Main Authors: Mike Hernandez, MS, J. Jack Lee, PhD, Beow Y. Yeap, ScD, Rong Ye, MS, Robert L. Foote, MD, Paul Busse, MD, PhD, Samir H. Patel, MD, Roi Dagan, MD, James Snider, MD, Nasiruddin Mohammed, MD, MBA, Alexander Lin, MD, Pierre Blanchard, MD, PhD, Scott B. Cantor, PhD, Menna Y. Teferra, MS, Kate Hutcheson, PhD, Pablo Yepes, PhD, Radhe Mohan, PhD, Zhongxing Liao, MD, Thomas F. DeLaney, MD, Steven J. Frank, MD
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Advances in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2452109420303651

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http://www.sciencedirect.com/science/article/pii/S2452109420303651

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