Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus

Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus

The polysialic acid (PSA) is a large glycan that is added to cell-surface proteins during their post-translational maturation. In the brain, PSA modulates distances between cells and controls the plasticity of the nervous system. In the hypothalamus, PSA is involved in many aspects of energy balance...

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Bibliographic Details
Main Authors: Xavier Brenachot, Thomas Gautier, Emmanuelle Nédélec, Valérie Deckert, Amélie Laderrière, Danaé Nuzzaci, Caroline Rigault, Aleth Lemoine, Luc Pénicaud, Laurent Lagrost, Alexandre Benani
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Neuroscience
Subjects:
polysialic acid
hypothalamus
atherosclerosis
HDL
LDL
synaptic plasticity
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00245/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00245/full

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