Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite

Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite

The mechanism by which the inflammatory enzyme prostaglandin H2 synthase-1 (PGHS-1) deactivates remains undefined. This study aimed to determine the stabilizing parameters of PGHS-1 and identify factors leading to deactivation by nitric oxide species (NOx). Purified PGHS-1 was stabilized when solubi...

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Bibliographic Details
Main Authors: Ruba S. Deeb, Gang Hao, Steven S. Gross, Muriel Laineé, Ju Hua Qiu, Brad Resnick, Elisar J. Barbar, David P. Hajjar, Rita K. Upmacis
Format: Article
Language:English
Published: Elsevier 2006-05-01
Series:Journal of Lipid Research
Subjects:
cyclooxygenase
eicosanoids
heme reconstitution
peroxidase activity
proteolysis
mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520332387

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http://www.sciencedirect.com/science/article/pii/S0022227520332387

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