De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity

De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity

Abstract Background Gene expression-based subtyping has the potential to form a new paradigm for stratified treatment of colorectal cancer. However, current frameworks are based on the transcriptomic profiles of primary tumors, and metastatic heterogeneity is a challenge. Here we aimed to develop a...

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Bibliographic Details
Main Authors: Seyed H. Moosavi, Peter W. Eide, Ina A. Eilertsen, Tuva H. Brunsell, Kaja C. G. Berg, Bård I. Røsok, Kristoffer W. Brudvik, Bjørn A. Bjørnbeth, Marianne G. Guren, Arild Nesbakken, Ragnhild A. Lothe, Anita Sveen
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Genome Medicine
Subjects:
Colorectal cancer
Liver metastasis
Transcriptomic subtyping
Gene expression profiling
Gene set enrichment analyses
Metastatic heterogeneity
Online Access:https://doi.org/10.1186/s13073-021-00956-1

Internet

https://doi.org/10.1186/s13073-021-00956-1

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