Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase

Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase

Abstract Background Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model of cough, we investigated the role of BK in the central sensitization o...

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Bibliographic Details
Main Authors: Fajer Al-Shamlan, Ahmed Z. El-Hashim
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Respiratory Research
Subjects:
Cough
Bradykinin
B2 receptors
TRPV1
TRPA1
Central sensitization
Online Access:http://link.springer.com/article/10.1186/s12931-019-1060-8

Internet

http://link.springer.com/article/10.1186/s12931-019-1060-8

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