SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis

SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis

Abstract Background Our previous studies reported that SHC SH2-domain binding protein 1 (SHCBP1) functions as an oncogene via promoting cell proliferations in synovial sarcoma (SS) cells. However, whether SHCBP1 has any effect on tumor metastasis remains unexplored. Methods The expression of SHCBP1...

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Bibliographic Details
Main Authors: Changliang Peng, Hui Zhao, Yan Song, Wei Chen, Xiaoying Wang, Xiaoli Liu, Cheng Zhang, Jie Zhao, Ji Li, Guanghui Cheng, Dongjin Wu, Chunzheng Gao, Xiuwen Wang
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
SHCBP1
EMT
Synovial sarcoma
Invasion
Metastasis
TGF-β1
Online Access:http://link.springer.com/article/10.1186/s13046-017-0616-z

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http://link.springer.com/article/10.1186/s13046-017-0616-z

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