Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation

Abstract Renal sympathetic nerves contribute to renal excretory function during volume expansion. We hypothesized that intact renal innervation is required for excretion of a fluid/electrolyte load in hypertensive chronic kidney disease (CKD) and normotensive healthy settings. Blood pressure, kidney...

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Bibliographic Details
Main Authors: Reetu R. Singh, Zoe McArdle, Harshil Singh, Lindsea C. Booth, Clive N. May, Geoffrey A. Head, Karen M. Moritz, Markus P. Schlaich, Kate M. Denton
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94221-5