α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

Abstract Genetic variation in a major histocompatibility complex II (MHCII)-encoding gene (HLA-DR) increases risk for Parkinson disease (PD), and the accumulation of MHCII-expressing immune cells in the brain correlates with α-synuclein inclusions. However, the timing of MHCII-cell recruitment with...

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Bibliographic Details
Main Authors: Ashley S. Harms, Vedad Delic, Aaron D. Thome, Nicole Bryant, Zhiyong Liu, Sidhanth Chandra, Asta Jurkuvenaite, Andrew B. West
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Acta Neuropathologica Communications
Subjects:
SNCA
Neuroinflammation
Neurodegeneration
Leukocytes
Microglia
Inclusion propagation
Online Access:http://link.springer.com/article/10.1186/s40478-017-0494-9

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http://link.springer.com/article/10.1186/s40478-017-0494-9

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