N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development

N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”, “erasers” and “readers”, respectively. Altere...

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Bibliographic Details
Main Authors: Yi Niu, Arabella Wan, Ziyou Lin, Xiongbin Lu, Guohui Wan
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Acta Pharmaceutica Sinica B
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383518302478