Keratin Retraction and Desmoglein3 Internalization Independently Contribute to Autoantibody-Induced Cell Dissociation in Pemphigus Vulgaris

Keratin Retraction and Desmoglein3 Internalization Independently Contribute to Autoantibody-Induced Cell Dissociation in Pemphigus Vulgaris

Pemphigus vulgaris (PV) is a potentially lethal autoimmune disease characterized by blister formation of the skin and mucous membranes and is caused by autoantibodies against desmoglein (Dsg) 1 and Dsg3. Dsg1 and Dsg3 are linked to keratin filaments in desmosomes, adhering junctions abundant in tiss...

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Bibliographic Details
Main Authors: Elisabeth Schlögl, Mariya Y. Radeva, Franziska Vielmuth, Camilla Schinner, Jens Waschke, Volker Spindler
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
pemphigus
keratin filaments
desmosome
cell adhesion
keratinocytes
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00858/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00858/full

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