Neuropathology and Therapeutic Intervention in Spinal and Bulbar Muscular Atrophy

Neuropathology and Therapeutic Intervention in Spinal and Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy (SBMA) is a hereditary motor neuron disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The histopathological finding in SBMA is loss of lower motor neurons in the anterior horn of the spinal cord as well as in the brainstem moto...

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Bibliographic Details
Main Authors: Haruhiko Banno, Masahisa Katsuno, Keisuke Suzuki, Fumiaki Tanaka, Gen Sobue
Format: Article
Language:English
Published: MDPI AG 2009-03-01
Series:International Journal of Molecular Sciences
Subjects:
spinal and bulbar muscular atrophy (SBMA)
polyglutamine
androgen receptor (AR)
leuprorelin acetate
Online Access:http://www.mdpi.com/1422-0067/10/3/1000/

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http://www.mdpi.com/1422-0067/10/3/1000/

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