<i>Neospora caninum</i>: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294

<i>Neospora caninum</i>: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294

Background: Bumped kinase inhibitors (BKIs) are potential drugs for neosporosis treatment in farm animals. BKI-1294 exposure results in the formation of multinucleated complexes (MNCs), which remain viable in vitro under constant drug pressure. We investigated the formation of BKI-1294 induced MNCs,...

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Bibliographic Details
Main Authors: Pablo Winzer, Nicoleta Anghel, Dennis Imhof, Vreni Balmer, Luis-Miguel Ortega-Mora, Kayode K. Ojo, Wesley C. Van Voorhis, Joachim Müller, Andrew Hemphill
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pathogens
Subjects:
bumped kinase inhibitor
calcium-dependent protein kinase
immunofluorescence
immunogold labeling
inner membrane complex
neosporosis
Online Access:https://www.mdpi.com/2076-0817/9/5/382

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https://www.mdpi.com/2076-0817/9/5/382

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