A Light-Controlled Allosteric Modulator Unveils a Role for mGlu4 Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex

A Light-Controlled Allosteric Modulator Unveils a Role for mGlu4 Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex

Metabotropic glutamate receptors (mGlus) are G Protein coupled-receptors that modulate synaptic transmission and plasticity in the central nervous system. Some act as autoreceptors to control neurotransmitter release at excitatory synapses and have become attractive targets for drug therapy to treat...

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Bibliographic Details
Main Authors: Simon Bossi, Romain Helleringer, Micaela Galante, Ester Monlleó, Ana Trapero, Xavier Rovira, Hervé Daniel, Amadeu Llebaria, Heather McLean
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
presynaptic metabotropic glutamate receptor 4
allosteric modulation
photo-pharmacology
cerebellar cortex
oxygen glucose deprivation
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00449/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00449/full

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