Adiponectin Reduces Bone Stiffness: Verified in a Three-Dimensional Artificial Human Bone Model In Vitro

Adiponectin Reduces Bone Stiffness: Verified in a Three-Dimensional Artificial Human Bone Model In Vitro

Primary human osteoblasts and osteoclasts incubated in a rotating coculture system without any scaffolding material, form bone-like tissue that may be used to evaluate effects of various compounds on mechanical strength. Circulating adiponectin has been found to be negatively associated with BMD and...

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Bibliographic Details
Main Authors: Sigrid Haugen, Jianying He, Alamelu Sundaresan, Astrid Kamilla Stunes, Kristin Matre Aasarød, Hanna Tiainen, Unni Syversen, Bjørn Skallerud, Janne Elin Reseland
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Endocrinology
Subjects:
adiponectin
bone stiffness
bone remodeling
osteospheres
three-dimensional culturing system
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00236/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2018.00236/full

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