Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion

Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion

ISWI chromatin remodeling ATPase SMARCA5 (SNF2H) is a well-known factor for its role in regulation of DNA access via nucleosome sliding and assembly. SMARCA5 transcriptionally inhibits the myeloid master regulator PU.1. Upregulation of SMARCA5 was previously observed in CD34+ hematopoietic progenito...

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Bibliographic Details
Main Authors: Tomas Zikmund, Helena Paszekova, Juraj Kokavec, Paul Kerbs, Shefali Thakur, Tereza Turkova, Petra Tauchmanova, Philipp A. Greif, Tomas Stopka
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
smarca5
snf2h
aml
leukemia
crispr
therapeutic target
Online Access:https://www.mdpi.com/1422-0067/21/6/2073

Internet

https://www.mdpi.com/1422-0067/21/6/2073

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