Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells

Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells

A new series of <i>N,N</i>-bis(alkanol)amine aryl diesters was synthesized and studied as dual P-glycoprotein (P-gp) and carbonic anhydrase XII inhibitors (CA XII). These hybrids should be able to synergistically overcome P-gp mediated multidrug resistance (MDR) in cancer cells. It was r...

Full description

Bibliographic Details
Main Authors: Elisabetta Teodori, Laura Braconi, Silvia Bua, Andrea Lapucci, Gianluca Bartolucci, Dina Manetti, Maria Novella Romanelli, Silvia Dei, Claudiu T. Supuran, Marcella Coronnello
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
MDR reversers
P-gp modulators
CA XII inhibitors
K562/DOX
LoVo/DOX
hybrid compounds
Online Access:https://www.mdpi.com/1420-3049/25/7/1748

Internet

https://www.mdpi.com/1420-3049/25/7/1748

Similar Items