Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells
A new series of <i>N,N</i>-bis(alkanol)amine aryl diesters was synthesized and studied as dual P-glycoprotein (P-gp) and carbonic anhydrase XII inhibitors (CA XII). These hybrids should be able to synergistically overcome P-gp mediated multidrug resistance (MDR) in cancer cells. It was r...
Main Authors: | Elisabetta Teodori, Laura Braconi, Silvia Bua, Andrea Lapucci, Gianluca Bartolucci, Dina Manetti, Maria Novella Romanelli, Silvia Dei, Claudiu T. Supuran, Marcella Coronnello |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-04-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/25/7/1748 |
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