Structure–Activity Relationship Studies Using Natural and Synthetic Okadaic Acid/Dinophysistoxin Toxins

Structure–Activity Relationship Studies Using Natural and Synthetic Okadaic Acid/Dinophysistoxin Toxins

Okadaic acid (OA) and the closely related dinophysistoxins (DTXs) are algal toxins that accumulate in shellfish and are known serine/threonine protein phosphatase (ser/thr PP) inhibitors. Phosphatases are important modulators of enzyme activity and cell signaling pathways. However, the interactions...

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Bibliographic Details
Main Authors: Michael J. Twiner, Gregory J. Doucette, Yucheng Pang, Chao Fang, Craig J. Forsyth, Christopher O. Miles
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Marine Drugs
Subjects:
cytotoxicity
diarrheic shellfish poisoning (DSP)
dinophysistoxin (DTX)
harmful algal bloom (HAB)
okadaic acid (OA)
protein phosphatase (PP)
structure–activity relationship (SAR)
Online Access:http://www.mdpi.com/1660-3397/14/11/207

Internet

http://www.mdpi.com/1660-3397/14/11/207

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