A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems

A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems

Abstract Background Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central nervous system and investigated the...

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Bibliographic Details
Main Authors: Daniela da Fonseca Pacheco, Ana Cristina Nogueira Freitas, Adriano Monteiro C. Pimenta, Igor Dimitri Gama Duarte, Maria Elena de Lima
Format: Article
Language:English
Published: SciELO 2017-01-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Peptide PnPP-19
Central antinociception
Phoneutria nigriventer
μ-opioid receptor
δ-opioid receptor
CB1 receptor
CB2 receptor
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100325&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100325&lng=en&tlng=en

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