Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques.

Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques.

SIV(mac239) infection of rhesus macaques (RMs) results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL) response, possibly due to the emergence of viral escape mutants that prevent recognition of infected cells by CTLs. To determine the anatomic origin of these SIV m...

Full description

Bibliographic Details
Main Authors: Thomas H Vanderford, Chelsea Bleckwehl, Jessica C Engram, Richard M Dunham, Nichole R Klatt, Mark B Feinberg, David A Garber, Michael R Betts, Guido Silvestri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3098234?pdf=render

Internet

http://europepmc.org/articles/PMC3098234?pdf=render

Similar Items