Increased metal content in the TDP-43A315T transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Increased metal content in the TDP-43A315T transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Disrupted metal homeostasis is a consistent feature of neurodegenerative disease in humans and is recapitulated in mouse models of Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and neuronal ceriod lipofuscinosis. While the definitive pathogenesis of neurodegenerative...

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Bibliographic Details
Main Authors: Theresa eDang, Nastasia eLim, Alexandra eGrubman, Qiao-Xin eLi, Irene eVolitakis, Anthony Robert White, Peter eCrouch
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
neurodegenerative disease
Amyotrophic lateral sclerosis (ALS)
zinc (Zn)
frontotemporal lobar degeneration (FTLD)
TAR DNA binding protein-43 (TDP-43)
copper (Cu)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00015/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00015/full

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