Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens

Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens

Cystic fibrosis is caused by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secretion. Here the authors show that exposure to bacteria triggers secretion in wild-type but not in pig models of cystic fibrosis, suggesting an impaired response to pathogens contributes...

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Bibliographic Details
Main Authors: Xiaojie Luan, George Belev, Julian S. Tam, Santosh Jagadeeshan, Noman Hassan, Paula Gioino, Nikolay Grishchenko, Yanyun Huang, James L. Carmalt, Tanya Duke, Teela Jones, Bev Monson, Monique Burmester, Tomer Simovich, Orhan Yilmaz, Veronica A. Campanucci, Terry E. Machen, L. Dean Chapman, Juan P. Ianowski
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00835-7

Internet

https://doi.org/10.1038/s41467-017-00835-7

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