Evaluating the Efficacies of Carbapenem/β-Lactamase Inhibitors Against Carbapenem-Resistant Gram-Negative Bacteria in vitro and in vivo

Evaluating the Efficacies of Carbapenem/β-Lactamase Inhibitors Against Carbapenem-Resistant Gram-Negative Bacteria in vitro and in vivo

BackgroundCarbapenem-resistant Gram-negative bacteria are a major clinical concern as they cause virtually untreatable infections since carbapenems are among the last-resort antimicrobial agents. β-Lactamases implicated in carbapenem resistance include KPC, NDM, and OXA-type carbapenemases. Antimicr...

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Bibliographic Details
Main Authors: Bassam El Hafi, Sari S. Rasheed, Antoine G. Abou Fayad, George F. Araj, Ghassan M. Matar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Microbiology
Subjects:
OXA-48
NDM-1
KPC
carbapenem
Avibactam
Relebactam
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00933/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00933/full

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