Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay

Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay

In vitro evaluation of P-glycoprotein (P-gp) inhibitory potential is now a regulatory issue during drug development, in order to predict clinical inhibition of P-gp and subsequent drug–drug interactions. Assays for this purpose, commonly based on P-gp-expressing cell lines and digoxin as a reference...

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Bibliographic Details
Main Authors: Elodie Jouan, Marc Le Vée, Abdullah Mayati, Claire Denizot, Yannick Parmentier, Olivier Fardel
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Pharmaceutics
Subjects:
P-glycoprotein
inhibition
drug–drug interactions
rhodamine 123
digoxin
Online Access:http://www.mdpi.com/1999-4923/8/2/12

Internet

http://www.mdpi.com/1999-4923/8/2/12

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