Lack of clastogenic effects of L-thyroxine in whole-blood cultured human lymphocytes

Lack of clastogenic effects of L-thyroxine in whole-blood cultured human lymphocytes

Thyroid hormones stimulate aerobic metabolism which may lead to oxidative stress accompanied by damage to various cellular macromolecules, including DNA. Previous comet assay studies have shown that thyroid hormones cause DNA damage due to the creation of reactive oxygen species (ROS). However, cyto...

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Bibliographic Details
Main Authors: Ninoslav Djelic, Dijana Djelic, Biljana Spremo-Potparevic, Lada Zivkovic, Biljana Markovic, Olivera Lozance, Milos Blagojevic
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2007-01-01
Series:Genetics and Molecular Biology
Subjects:
thyroxine
human lymphocytes
chromosome aberrations
mitotic index
ROS
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000600019

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000600019

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