Disruption of Smad4 expression in T cells leads to IgA nephropathy-like manifestations.

Disruption of Smad4 expression in T cells leads to IgA nephropathy-like manifestations.

The link between glomerular IgA nephropathy (IgAN) and T helper 2 (Th2) response has been implicated, however, the mechanisms are poorly defined because of the lack of an appropriate model. Here we report a novel murine model characterized by lineage-restricted deletion of the gene encoding MAD homo...

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Bibliographic Details
Main Authors: Hiroyuki Inoshita, Byung-Gyu Kim, Michifumi Yamashita, Sung Hee Choi, Yasuhiko Tomino, John J Letterio, Steven N Emancipator
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223846/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223846/pdf/?tool=EBI

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