In vitro tripanocidal effect of 1,8-dioxooctahydroxanthenes (xanthenodiones) and tetraketones and improvement of cardiac parameters in vivo

In vitro tripanocidal effect of 1,8-dioxooctahydroxanthenes (xanthenodiones) and tetraketones and improvement of cardiac parameters in vivo

Objective: Trypanosoma cruzi infection affects millions of people worldwide, and the drugs available for its treatment have limited efficacy. 1,8-Dioxooctahydroxanthenes and tetraketones are compounds with important biological applications. The aim of this study was to assess the trypanocidal and in...

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Bibliographic Details
Main Authors: Ana Paula de Jesus Menezes, Milene Lopes da Silva, Wagner Luiz Pereira, Guilherme de Paula Costa, Aline Luciano Horta, Andréa Aparecida Santos Mendonça, Ana Claudia Alvarenga Carneiro, Debora Maria Soares de Souza, Rômulo Dias Novaes, Róbson Ricardo Teixeira, André Talvani
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Trypanosoma cruzi
Xanthenodiones
Tetraketones
Inflammation
Heart damage
Benznidazole
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716520300977

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http://www.sciencedirect.com/science/article/pii/S2213716520300977

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