Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.

Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.

There has been much interest in targeting intracellular redox pathways as a therapeutic approach for cancer. Given recent data to suggest that the redox status of extracellular protein thiol groups (i.e. exofacial thiols) effects cell behavior, we hypothesized that redox active anti-cancer agents wo...

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Bibliographic Details
Main Authors: Jolanta Skalska, Paul S Brookes, Sergiy M Nadtochiy, Shannon P Hilchey, Craig T Jordan, Monica L Guzman, Sanjay B Maggirwar, Margaret M Briehl, Steven H Bernstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2780735?pdf=render

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http://europepmc.org/articles/PMC2780735?pdf=render

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