Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors.

Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors.

BACKGROUND: Threonine Aspartase 1 (Taspase1) mediates cleavage of the mixed lineage leukemia (MLL) protein and leukemia provoking MLL-fusions. In contrast to other proteases, the understanding of Taspase1's (patho)biological relevance and function is limited, since neither small molecule inhibi...

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Main Authors: Shirley K Knauer, Verena Fetz, Jens Rabenstein, Sandra Friedl, Bettina Hofmann, Samaneh Sabiani, Elisabeth Schröder, Lena Kunst, Eugen Proschak, Eckhard Thines, Thomas Kindler, Gisbert Schneider, Rolf Marschalek, Roland H Stauber, Carolin Bier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3102056?pdf=render

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http://europepmc.org/articles/PMC3102056?pdf=render

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