Genetic Bias, Diversity Indices, Physiochemical Properties and CDR3 Motifs Divide Auto-Reactive from Allo-Reactive T-Cell Repertoires

Genetic Bias, Diversity Indices, Physiochemical Properties and CDR3 Motifs Divide Auto-Reactive from Allo-Reactive T-Cell Repertoires

The distinct properties of allo-reactive T-cell repertoires are not well understood. To investigate whether auto-reactive and allo-reactive T-cell repertoires encoded distinct properties, we used dextramer enumeration, enrichment, single-cell T-cell receptor (TCR) sequencing and multiparameter analy...

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Bibliographic Details
Main Authors: Oscar L. Haigh, Emma J. Grant, Thi H. O. Nguyen, Katherine Kedzierska, Matt A. Field, John J. Miles
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
T-cell
T-cell receptor
T-cell repertoire
T-cell alloreactivity
Online Access:https://www.mdpi.com/1422-0067/22/4/1625

Internet

https://www.mdpi.com/1422-0067/22/4/1625

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