Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy

Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy

Abstract Microglia are resident macrophages of the central nervous system, and their unique molecular signature is dependent upon CSF-1 signaling. Previous studies have demonstrated the importance of CSF-1R in survival and development of microglia in animal models, but the findings are of uncertain...

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Bibliographic Details
Main Authors: Liam Kempthorne, Hyejin Yoon, Charlotte Madore, Scott Smith, Zbigniew K. Wszolek, Rosa Rademakers, Jungsu Kim, Oleg Butovsky, Dennis W. Dickson
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Acta Neuropathologica Communications
Subjects:
CSF-1R-related leukoencephalopathy
Hereditary diffuse leukoencephalopathy with spheroids (HDLS)
Adult leukoencephalopathy with spheroids and pigmented glia (ALSP)
CSF-1R
CSF-1
Microglia
Online Access:http://link.springer.com/article/10.1186/s40478-020-00947-0

Internet

http://link.springer.com/article/10.1186/s40478-020-00947-0

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