Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis

Abstract Aging is a complex biological process regulated by multiple cellular pathways and molecular mechanisms including epigenetics. Using genome-wide DNA methylation data measured in a large collection of Scottish old individuals, we performed discovery association analysis to identify age-methyl...

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Bibliographic Details
Main Authors: Shuxia Li, Lene Christiansen, Kaare Christensen, Torben A. Kruse, Paul Redmond, Riccardo E. Marioni, Ian J. Deary, Qihua Tan
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08346-7