Stochasticity of intranuclear biochemical reaction processes controls the final decision of cell fate associated with DNA damage.

Stochasticity of intranuclear biochemical reaction processes controls the final decision of cell fate associated with DNA damage.

A massive integrative mathematical model of DNA double-strand break (DSB) generation, DSB repair system, p53 signaling network, and apoptosis induction pathway was constructed to explore the dominant factors of unknown criteria of cell fate decision. In the proposed model, intranuclear reactions wer...

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Bibliographic Details
Main Authors: Kazunari Iwamoto, Hiroyuki Hamada, Yukihiro Eguchi, Masahiro Okamoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4086823?pdf=render

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http://europepmc.org/articles/PMC4086823?pdf=render

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