Transcriptomic and Metabolic Network Analysis of Metabolic Reprogramming and IGF-1 Modulation in SCA3 Transgenic Mice

Transcriptomic and Metabolic Network Analysis of Metabolic Reprogramming and IGF-1 Modulation in SCA3 Transgenic Mice

Spinocerebellar ataxia type 3 (SCA3) is a genetic neurodegenerative disease for which a cure is still needed. Growth hormone (GH) therapy has shown positive effects on the exercise behavior of mice with cerebellar atrophy, retains more Purkinje cells, and exhibits less DNA damage after GH interventi...

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Bibliographic Details
Main Authors: Yu-Te Lin, Yong-Shiou Lin, Wen-Ling Cheng, Jui-Chih Chang, Yi-Chun Chao, Chin-San Liu, An-Chi Wei
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
spinocerebellar ataxia type 3
insulin-like growth factor 1
RNA-seq
context-specific metabolic networks
Online Access:https://www.mdpi.com/1422-0067/22/15/7974

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https://www.mdpi.com/1422-0067/22/15/7974

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