Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor

Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor

Diabetic cardiomyopathy (DCM) is a severe complication of type 1 diabetic (T1D) patients, manifested as combined diastolic and systolic dysfunction. DCM is associated with impaired calcium homeostasis secondary to decreased calcium-sensitive receptor (CaSR) expression. Spermine, a direct agonist of...

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Bibliographic Details
Main Authors: Yuehong Wang, Junting Chen, Siwei Li, Xinying Zhang, Zuoming Guo, Jing Hu, Xiaoting Shao, Ningyang Song, Yajun Zhao, Hongzhu Li, Guangdong Yang, Changqing Xu, Can Wei
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Redox Biology
Subjects:
Calcium sensitive receptor
Diabetic cardiomyopathy
ER stress
Nrf2-ROS-p53-MuRF1 axis
Spermine
Unfolded protein response
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719315496

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http://www.sciencedirect.com/science/article/pii/S2213231719315496

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