An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence

An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence

A great deal of interest has been focused recently on the habenula and its critical role in aversion, negative-reward and drug dependence. Using a conditional mouse model of the ACh-synthesizing enzyme choline acetyltransferase (Chat), we report that local elimination of acetylcholine (ACh) in media...

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Bibliographic Details
Main Authors: Silke Frahm, Beatriz Antolin-Fontes, Andreas Görlich, Johannes-Friedrich Zander, Gudrun Ahnert-Hilger, Ines Ibañez-Tallon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
cotransmission
vesicular synergy
habenula
presynaptic facilitation
nicotine dependence
cholinergic
Online Access:https://elifesciences.org/articles/11396

Internet

https://elifesciences.org/articles/11396

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