Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection.

An imbalance between pro-survival and pro-death pathways in brain cells can lead to neuronal cell death and neurodegeneration. While such imbalance is known to be associated with alterations in glutamatergic and Ca(2+) signaling, the underlying mechanisms remain undefined. We identified the protein...

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Bibliographic Details
Main Authors: Mélissa Farinelli, Fabrice D Heitz, Benjamin F Grewe, Shiva K Tyagarajan, Fritjof Helmchen, Isabelle M Mansuy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3316588?pdf=render