Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

Background: Doxorubicin, an anthracycline chemotherapeutic agent, is widely used in the treatment of many cancers. However, doxorubicin posts a great risk of adverse cardiovascular events, which are thought to be caused by oxidative stress. We recently reported that the ubiquitin E3 ligase TRIM21 in...

Full description

Bibliographic Details
Main Authors: Kai Hou, Jianliang Shen, Junrong Yan, Chuannan Zhai, Jingxia Zhang, Ji-An Pan, Ye Zhang, Yaping Jiang, Yongbo Wang, Richard Z. Lin, Hongliang Cong, Shenglan Gao, Wei-Xing Zong
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:EBioMedicine
Subjects:
TRIM21
Antioxidant
Doxorubicin
Cardiotoxicity
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421002498

Internet

http://www.sciencedirect.com/science/article/pii/S2352396421002498

Similar Items