Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception

Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception

<p>Abstract</p> <p>Background</p> <p>The Transient Receptor Potential (TRP) ion channel TRPA1 is a key player in pain pathways. Irritant chemicals activate ion channel TRPA1 via covalent modification of N-terminal cysteines. We and others have shown that 15-Deoxy-Δ12, 1...

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Bibliographic Details
Main Authors: Weng Yingqi, Batista-Schepman Patricia A, Barabas Marie E, Harris Eli Q, Dinsmore Thomas B, Kossyreva Elena A, Foshage Audra M, Wang Michelle H, Schwab Matthew J, Wang Victoria M, Stucky Cheryl L, Story Gina M
Format: Article
Language:English
Published: SAGE Publishing 2012-09-01
Series:Molecular Pain
Subjects:
TRPA1
15d-PGJ<sub>2</sub>
Mustard oil
Negative modulation
Mechanical hypersensitivity
Online Access:http://www.molecularpain.com/content/8/1/75

Internet

http://www.molecularpain.com/content/8/1/75

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