Alternative splicing perturbation landscape identifies RNA binding proteins as potential therapeutic targets in cancer

Alternative splicing perturbation landscape identifies RNA binding proteins as potential therapeutic targets in cancer

Alternative splicing (AS) plays an important role in gene regulation, and AS perturbations are frequently observed in cancer. RNA binding protein (RBP) is one of the molecular determinants of AS, and perturbations in RBP-gene network activity are causally associated with cancer development. Here, we...

Full description

Bibliographic Details
Main Authors: Junyi Li, Tao Pan, Liuxin Chen, Qi Wang, Zhenghong Chang, Weiwei Zhou, Xinhui Li, Gang Xu, Xia Li, Yongsheng Li, Yunpeng Zhang
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
RNA binding protein
alterative splicing
regulatory network
cancer
therapeutic targets
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000998

Internet

http://www.sciencedirect.com/science/article/pii/S2162253121000998

Similar Items