Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction.

Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction.

Innate immune activation via IL-1R or Toll-like receptors (TLR) contibutes to acute kidney injury but its role in tissue remodeling during chronic kidney disease is unclear. SIGIRR is an inhibitor of TLR-induced cytokine and chemokine expression in intrarenal immune cells, therefore, we hypothesized...

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Bibliographic Details
Main Authors: Veronika Skuginna, Maciej Lech, Ramanjaneyulu Allam, Mi Ryu, Sebastian Clauss, Heni Eka Susanti, Christoph Römmele, Cecilia Garlanda, Alberto Mantovani, Hans-Joachim Anders
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3081345?pdf=render

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http://europepmc.org/articles/PMC3081345?pdf=render

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