Evaluation of immunogenicity and protective efficacy elicited by Mycobacterium bovis BCG overexpressing Ag85A protein against Mycobacterium tuberculosis aerosol infection

Evaluation of immunogenicity and protective efficacy elicited by Mycobacterium bovis BCG overexpressing Ag85A protein against Mycobacterium tuberculosis aerosol infection

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is currently the only vaccine available against tuberculosis (TB), however, it has various levels of efficacy for preventing pulmonary TB. In this study, a recombinant BCG (rBCG::Ag85A) strain overexpressing the immunodominant Ag85A antigen was cons...

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Bibliographic Details
Main Authors: Zheng Zhong Xu, Xiang eChen, Ting eHu, Chuang eMeng, Xiao Bo Wang, Yan eRao, Xiao Ming Zhang, Yue Lan Yin, Zhi Ming Pan, Xin An Jiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium tuberculosis
Immunogenicity
protective efficacy
Ag85A
Recombinant BCG
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00003/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00003/full

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