Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death

Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death

Abstract Background Oxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its selective RPE cell damage makes it as a reproducible model of AMD. Although NaIO3 is an oxidat...

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Bibliographic Details
Main Authors: Chi-Ming Chan, Duen-Yi Huang, Ponarulselvam Sekar, Shu-Hao Hsu, Wan-Wan Lin
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Biomedical Science
Subjects:
Retinal epithelium
Reactive oxygen species
Sodium iodate
Mitochondrial dynamics
Autophagy
Age-related macular degeneration
Online Access:http://link.springer.com/article/10.1186/s12929-019-0531-z

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http://link.springer.com/article/10.1186/s12929-019-0531-z

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