Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

Abstract Background Pancreatic cancer is generally acknowledged as the most common primary malignant tumor, and it is known to be resistant to conventional chemotherapy. Novel, selective antitumor agents are pressingly needed. Methods CCK-8 and colony formation assay were used to investigate the cel...

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Bibliographic Details
Main Authors: Zihang Xu, Fei Zhang, Chao Bai, Chao Yao, Hairong Zhong, Chunpu Zou, Xiao Chen
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic cancer
Sophoridine
Apoptosis
ROS
Online Access:http://link.springer.com/article/10.1186/s13046-017-0590-5

Internet

http://link.springer.com/article/10.1186/s13046-017-0590-5

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