Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells
Abstract Background Pancreatic cancer is generally acknowledged as the most common primary malignant tumor, and it is known to be resistant to conventional chemotherapy. Novel, selective antitumor agents are pressingly needed. Methods CCK-8 and colony formation assay were used to investigate the cel...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2017-09-01
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Series: | Journal of Experimental & Clinical Cancer Research |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13046-017-0590-5 |