Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?

Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?

Abstract Mutations in the propeller domain of Plasmodium falciparum kelch 13 (Pfk13) gene are associated with artemisinin resistance in Southeast Asia. Artemisinin resistance is defined by increased ring survival rate and delayed parasite clearance half-life in patients. Additionally, an amplificati...

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Bibliographic Details
Main Authors: Francis Foguim Tsombeng, Mathieu Gendrot, Marie Gladys Robert, Marylin Madamet, Bruno Pradines
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
Anti-malarial drug
Resistance
In vitro
Dihydroartemisinin
Online Access:http://link.springer.com/article/10.1186/s12936-019-2916-6

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http://link.springer.com/article/10.1186/s12936-019-2916-6

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