N-Glycosylation influences human corticosteroid-binding globulin measurements

N-Glycosylation influences human corticosteroid-binding globulin measurements

Objective: Discrepancies in ELISA measurements of human corticosteroid-binding globulin (CBG) using detection monoclonal antibodies that recognize an epitope (9G12) within its reactive center loop (RCL), versus an epitope (12G2) in a different location, have suggested that CBG with a proteolytically...

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Bibliographic Details
Main Authors: Lesley A Hill, Zeynep Sumer-Bayraktar, John G Lewis, Eva Morava, Morten Thaysen-Andersen, Geoffrey L Hammond
Format: Article
Language:English
Published: Bioscientifica 2019-08-01
Series:Endocrine Connections
Subjects:
glycosylation
congenital disorders of glycosylation
protein structure
steroid binding
monoclonal antibodies
epitopes
Online Access:https://ec.bioscientifica.com/view/journals/ec/8/8/EC-19-0242.xml

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https://ec.bioscientifica.com/view/journals/ec/8/8/EC-19-0242.xml

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